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Day 47: COVID-19 “In the Wild”
The number of countries now reporting COVID-19 cases is 98. The US is currently at 335 cases with 17 deaths and 15 recoveries. Iran is reporting 1,699 recoveries — 1,551 more than recoveries reported by South Korea who has 1,218 more total cases reported than Iran. Maybe it’s just me, but I am doubting the Iranian numbers.
There is a lot of criticism being leveled at the federal government over the lack of “test kits.” I am not sure what that really means. I am still trying to sort out the testing protocol and how that is affecting the US ability to respond to the pandemic. In Vice President Pence’s press conference Friday, he indicated that there would be a press conference today by I think a CDC or NIH official to focus specifically on testing. I hope to be better informed afterward. Here is the issue: Data suggests that one can carry the virus asymptomatically for as much as 14 days (some outliers up to 27 days), and after recovery for some unspecified period.
Normal medical practice involves “differential diagnosis.” That is, many diseases present with common symptoms. If you ever search the internet for “headache,” “muscle cramps,” etc., you will find a long list of conditions to which those symptoms are associated. The task of the doctor is to consider the various symptoms in combination and determine that it is disease A versus disease B, C, D, etc. Testing aids in differential diagnosis as it adds information for the diagnosis. Most tests are not specific to a disease. Tests that are specific to a disease are diagnostic gold.
So what does this all mean? When you are presented with a public health crisis the question is who do you test? People who are asymptomatic do not normally present themselves to a doctor for any testing. But it is important to test asymptomatic people in order to anticipate and control disease progress if you are dealing with an unknown illness of unknown virulence and consequence. Testing only symptomatic people is helpful in developing a treatment plan for that individual and documenting the history of the disease, but it doesn’t stop the spread of the disease. If you have a disease-specific test that is accurate, easy to produce, easy to distribute, and easy to administer, the problem is simple. Just start rounding people up and test them. But is there such a thing for COVID-19, or is it a unicorn?
There is a mysterious case in Australia with a US connection. A doctor from Victoria was traveling in the US and became ill during a flight between Denver and San Francisco on February 27. He continued on to Australia, arriving home February 29 (having crossed the international dateline), and spent the next few days seeing patients, including at a nursing home. He tested positive for COVID-19 on Thursday and is self-quarantined. Apparently what symptoms he has are not severe enough to be hospitalized. That’s all well and good for the doctor but the health officials are busy tracking his contacts including about 70 patients, the office and nursing home staff, and flight passengers both in the US leg and the transpacific flight.
The puzzling part is where in the US did the doctor get exposed? Nothing in the articles about this doctor indicate where and why he was traveling in the US. Conference? Vacation? Visiting friends and/or relatives? Did he have knowing contact with someone from China, Italy, South Korea, or Iran? Was this “community spread” that just caught the doctor as he was passing through? Where? The health officials think the doctor was “probably” exposed in the US. We are left to presume that his travel itinerary put him in the US for a sufficient length of time that it is unlikely that he was infected before he arrived in the US.
The Grand Princess is now accounting for 30 US cases — 21 currently onboard and 9 earlier passengers from a February voyage, including 1 death. The ship will apparently be permitted to berth in a non-commercial port where all passengers will be screened/tested before departing to wherever. There are several possibilities but if I was to just guess it might be Mare Island a former Navy Base at the north end of San Pablo Bay.
[Note: Links to all my COVID-19 posts can be found here.]
Worldometers news updates for March 6 and 7:
Published in GeneralMarch 7 (GMT):
- 13 new cases in Austria [source]
- 42 new cases in the UK [source]
- 6 new cases in Denmark [source]
- United States: only 1,895 people have been tested for the coronavirus so far, The Atlantic found
- 60 new cases in the Netherlands [source]
- 1 new case in Cambodia: a 38-year old man who had come into contact with the first case [source]
- 8 new cases and 8 new discharges in Singapore [source]
- 99 new cases and 2 new deaths in Spain [source] [source]
- 2 new cases in Saudi Arabia coming from Iran and Iraq [source]
- 24 new cases in Sweden [source]
- 2 new cases in Romania: [source]
– a 15-years-old young woman in in Timisoara attending the same school (but in another class) where 2 other students have already been diagnosed with Covid-19. She had a fever of 39.5 degrees and coughing, but her conditions are improving.
– the 16-years-old daughter of the 40-year-old man who tested positive in Hunedoara. They had also traveled on the same plane. She is asymptomatic for now- 4 new cases in Slovenia: [source]
– a Slovenian citizen who traveled to Italy (including Venice) for two weeks
– a close contact with an infected doctor from Metlika
– a Slovenian citizen who came from Austria, where he fell ill
a man who traveled through Italy to Spain with his family- 63 new cases and 2 new deaths in France [source]
- 1 new case in Poland: a person traveling with patient “zero” in the bus from Germany to Poland [source]
- 60 new cases in Belgium [source] bringing the total to 169 “Most of the positive patients have recently traveled, but we are seeing more and more local infections,” said a FPS Public Health official, adding that “the number of cases detected has not doubled. It is therefore possible that the return effect from travelers from northern Italy may end” [source]
- 1 new case in South Africa: a 39-year-old woman from Gauteng who was part of the same group of 10 people that recently traveled from Italy [source]
- 6 new cases in Bahrain [source]
- 3 new cases in India: 2 are from Ladakh with travel history to Iran and one is from Tamil Nadu with travel history to Oman[source]
- 3 new cases in Afghanistan in the western province of Herat which borders Iran. Afghanistan’s health ministry spokesman, Wahidullah Mayar, expressed concern about the vulnerability of Afghanistan’s border with Iran and added that the cost of testing would be a strain on Afghanistan’s resource-strapped health system. Each test kit – which can test around 50 cases – cost around $1600, he said [source]
- 1 new case in Croatia: a person in Varaždin who is a close contact of a previous case. “Patient zero” in Croatia is a young man who came from Italy [source]
- 4 new cases in Finland: 2 adults in Pirkanmaa who were on the same traveling group from northern Italy as those previously infected in Finland, and 2 man in Uusimaa who returned fromnorthern Italy [source]
- 3 new cases in Georgia “Please, don’t panic. There is no reason to panic” said the Head of the Georgian National Centre for Disease Control Amiran Gamkrelidze, noting that the most dangerous country for Georgia for now is Italy as most people who have tested positive for COVID-19 have arrived from there [source]
- 1,076 new cases and 21 new deaths in Iran [source]
- 47 new cases in Germany [source]
- 2 new cases in Slovakia: the son and wife of the man who was diagnosed yesterday. The son, who had been to Venice, Italy between February 14 and 15 and did not show any symptoms of the virus, has been identified as “patient zero” (the first contact patient in Slovakia). All flights from the Slovak international airports to Italy will be banned as of Monday, March 9 [source]
- 10 new cases in Malaysia [source]
- 3 new cases in Vietnam [source] including a 27-year-old patient who had been to the South Korean city of Daegu, returned to Vietnam on a Vietjet flight on Wednesday and was quarantined upon his landing, the ministry said in a statement [source]
- 2 new cases in the Philippines of local transmission, prompting the Department of Health to raise the nationwide alert level. New cases are a 59-year-old man and a 62-year-old Filipino man from Cainta (Rizal province) with no recent travel history abroad. The government’s contract tracing teams have yet to determine how he contracted the virus [source]
- 1 new case in Qatar: a Qatari citizen who had returned from Iran recently [source]
- 1 new case in Hungary: a 70-year-old Hungarian man with pre-existing diseases, currently being quarantined and treated at the Central Hospital of Southern Pest. “He was probably infected by his son living abroad, who visited him in mid-February after visiting Italy and Paris” according to the Hungarian government’s report [source]
- 2 new cases in Portugal: a 20-years-old and a 60-years-old women admitted to the hospital in São João, both with connections to one of the infected people in the same hospital [source]
- 3 new cases in Kuwait [source]
- 1st case in Malta: a 12-year-old Italian girl who had returned, via Rome, from a holiday trip with her family in northern Italy on Tuesday. She was in self-quarantine and is now isolated in an infectious diseases unit at Mater Dei Hospital. “The children did not go to school and the parents did not go to work or leave the house. Their contact with other people was minimal” [source]
- 2 new cases in Thailand: “both are Thai males aged 40″ according to the Ministry of Public Health [source]
- 2 new cases in Algeria: 1 belongs to the same family as the 16 already infected last week; 1 comes from Europe (specific country not provided) [source]
- 1 new case in Greece: a 48-years old man in the Sterea region who was part of the group returning from a trip in Israel and Egypt [source]
- 1 new case in Ecuador [source]
- 2 new cases in Switzerland [source]
- 7 new cases in Norway [source]
- 15 new cases in Japan [source] [source]
- 1 new case in Brazil: a patient in Rio de Janeiro who had recently traveled abroad [source]
- 16 new cases and 2 new deaths in the United States:
2 new deaths and 3 new cases in Florida (first deaths on the east coast) [source]1 new case in California (Alameda County): a former passenger on the now-quarantined Grand Princess cruise ship, an older adult who has underlying health conditions and is currently hospitalized. Alameda County’s Public Health Department is urging all residents who were on the Grand Princess cruise from Feb. 11 to Feb. 21 to get tested if they are experiencing any symptoms [source]First 2 cases in South Carolina: an elderly woman in Kershaw County who has been hospitalized and an adult woman from Charleston County who had recently traveled to France and Italy [source]1 new case in Illinois: a woman in her 50s who works as an aide at a Chicago high school [source]1st case in Utah: the patient was a passenger of the Grand Princess cruise ship [source]6 new cases in Colorado [source]1st case in Hawaii: a former passenger of the Grand Princess cruise ship (that docked on Oahu in late February) who did not feel well after a few days after returning home and went to see their doctor. The Department of Health said, “We don’t believe the patient had close contact with anyone else, but we’re still investigating.” [source]1 in New Jersey: a male in his 50s hospitalized at Englewood Hospital and Medical Center in Bergen County [source]- 448 new cases and 5 new deaths in South Korea [source]
- 1 new case in New Zealand: a woman in her 40s, partner of the third case [source]
- 1 new case in Australia (Victoria): a doctor who had recently returned from the US [source]
- 99 new cases (74 in Hubei), 28 new deaths (all in Hubei) and 1,678 new discharges occurred in China on March 6, as reported by the National Health Commission (NHC) of China. [source]
March 6:
- 98 new cases and 3 new deaths in the United States, including:
– 1 new case in Rhode Island (third in the state): a female in her 60s, now at home with mild symptoms. who had direct, face-to-face contact with a confirmed case in New York in late February [source]
– 1st case in Nebraska: a woman in her 30s from Douglas county who recently returned from England at the end of February. She started experiencing symptoms and was hospitalized at Methodist Hospital on March 5 [source]
– 1st case in Connecticut: a nurse at Danbury Hospital [source]
– 9 new cases and 3 new deaths in Washington state [source] [source]
– 1st case in Oklahoma: a man in his 50s resident in Tulsa County [source]
– 11 new cases in Calfornia:– 4 in Santa Clara County [source]
– 3 in Contra Costa County [source]
– 1 in Yolo County [source]
– 3 in Placer County who had traveled on the Grand Princess cruise ship from San Francisco to Mexico Feb. 11-21. Two had mild symptoms that have already resolved; the third currently has mild symptoms. All three are isolated at home and none required hospitalization. [source]– 21 on the Grand Princess cruise ship off California [source]
– 1st case in Kentucky, Lexington [source]
– 3 in Colorado: 2 residents of Denver [source] and of Colorado Springs: a man in his 40s who had traveled recently to California [source]
– 1st case in Minnesota: an elderly person who had traveled on a cruise ship that had a confirmed case [source]
– 1 in Nevada: the case has a family member who is a student at Huffaker Elementary School in Reno, which has been closed “out of an abundance of caution” [source]
– 1 in Massachusetts: a parent in Wellesley with children in the Upham and Wellesley middle schools, were students were dismissed early in order to fully clean and sanitize the buildings [source]
– 1 in Georgia [source]
– 1 in Indiana (1st in the state): an adult from Marion County who had traveled to Boston recently and had been at an event (Cambridge-based Biogen’s Boston conference) where other people have also tested positive. They returned to Indiana on Wednesday, March 4. [source]
– 1 in North Carolina (Chatham County): a man who had recently returned from Italy
– 2 in Pennsylvania (1st in the state) [source]
– 22 in New York state [source] [source]– 8 in Westchester County
– 3 in Nassau County [source]
– 11 connected to the original New Rochelle case– first 2 cases in Colorado (Summit County): 1 is a 30-year old man who had traveled to Italy in February and was in contact with a confirmed case outside of Colorado. [source]
– first 3 cases in Maryland (Montgomery County): they had all recently traveled overseas [source]- 8 new cases and 1 new death in Iraq [source]
- 1st case in Costa Rica: an American woman from New York [source]
- 1 new case in Luxembourg [source]
- 5 new cases in Argentina: 4 in Buenos Aires, 1 in Córdoba. They had all recently traveled to Europe [source]
- 1st case in Colombia: a 19-year-old girl in Bogotá who was studying in Milan, Italy [source][source]
- 23 new cases in Austria [source] Several students and teachers affected. From now on, direct flights to Iran, South Korea and the two northern Italian cities of Milan and Bologna will no longer be carried. In addition, there are going to be “one-off health checks” on the borders with Italy. Those arriving from regions where there are travel warnings must provide confirmation from a doctor that they are not infected. [source]
- 5 new cases in Ireland: [source]
a male associated with travel from northern Italy
a female who is a contact of a confirmed case
a female healthcare worker in the south of the country who was in contact with a confirmed case
a male from the south of the country with a travel history which is being investigated
a female associated with travel from northern Italy- 2 new cases in North Macedonia [source]
- 9 new cases in Palestine (Bethlehem) [source]
- 230 new cases and 2 new deaths in France [source]
- 119 new cases and 5 new deaths in Spain [source]
- 778 new cases and 49 new deaths in Italy. Total cases: 4,636. Total deaths: 197. Active cases: 3,916.
– Among the 3,916 active cases, 2,394 (61%) are hospitalized, 462 of which (representing 12% of active cases) are in intensive care.
– Among the 720 closed cases, 523 (73%) have recovered, 197 (27%) have died.- 6 new cases in Lebanon: [source]
- 1 new case in Slovenia:
– a doctor who had traveled abroad and had returned home via Italy [source]
– a healthcare worker [source]- 1 new case in Vietnam: a 23-year old woman who had traveled to France, the UK and Italy [source]
- 4 new cases in Israel [source]
- 1 new case in Bosnia and Herzegovina: a middle-aged person who lives in Celinac who was in close contact with a previously confirmed case [source]
- 94 new cases in Switzerland [source]
- 4 new cases in Poland: [source]
– a man who rode on the same bus as the first case
– two people who had recently returned from Italy
– 1 person from Wrocław- 17 new cases in the United Arab Emirates including a 17-year old student [source]
- 3 new cases in Romania:
latest case: a 40-year old man from Hunedoara who had recently visited Bergamo, Italy [source]
– a 51-year-old woman, admitted to Craiova, who came in contact with the Suceava case [source]
– a young classmate of the 16-year-old boy who was diagnosed with coronavirus previously. The young woman has been transferred to the Victor Babes hospital in Timisoara [source]- 1 new case in Croatia [source]
- 3 new cases in Qatar: 2 Qatari citizens and a family member of another nationality who had been evacuated from Iran. They are in isolation and in stable condition [source]
- 8 new cases in Iceland [source]
- 1st case in Togo: a 42-year old woman from Lome who had visited Benin, Germany, France and Turkey in late February and early March. [source]
- 6 new cases in the Czeck Republic (3 added while the press conference announcing 3 new cases was in progress) [source] [source]
- 47 new cases and 1 new death in the UK, including: [source]
– First Birmingham coronavirus case [source]
– 5 new cases in Scotland, bringing the total to 11: Tayside, Ayrshire and Arran, Forth Valley, Greater Glasgow and Clyde, Grampian, Fife and Lothian [source]
– 2 British Airways baggage handlers [source]- 4 new cases in Portugal: 3 are in the hospital center of São João, in Porto and “have an epidemiological link to previous cases”, which indicates that the source of the infection is in Italy. The other case, for which no information was provided, is receiving treatment in a health care in Lisbon. [source]
- 125 new cases in Germany [source]
- 64 new cases and 2 new deaths in Spain [source]
- 1 new case in Taiwan: a woman in her 50s [source]
- 1 new case in Thailand: British businessman who left London on Feb. 28 and changed planes in Hong Kong on Feb. 29 before arriving in Thailand. He was in Hong Kong for about eight hours. [source]
- 5 new cases in Bahrain [source]
- 1 new case in the Dominican Republic (second case in the country): a Canadian tourist who was staying at a hotel in Bayahibe [source]
- 6 new cases in Russia. All newly detected cases of coronavirus in the Russian Federation are “imported” from Italy [source] [source]
- 46 new cases and 1st death in the Netherlands: an 86-year-year old man in Rotterdam whose source of infection is unknown [source] [source]
- 2 new cases in San Marino [source]
- 1st case in Peru: a 25-year-old man who was in Spain, France and the Czech Republic [source]
- 5 new cases in Brazil including the first in Bahia: a 34-year-old woman, resident of Feira de Santana, who was in Italy and returned to Brazil on Feb. 25 [source] [source] [source]
- 3 new cases in Denmark [source]
- 13 new cases in Singapore (largest single-day increase) [source]
- 14 new cases in Greece (Zakynthos): part of the travel group who returned from the Holy Land in Israel. 3 from this group are in serious condition [source]
- 3 new cases in Azerbaijan: they had all recently traveled to Iran [source]
- 12 new cases in Egypt on a Nile cruise ship heading to the southern city of Luxor from Aswan [source]
- 1st case in Slovakia: a patient aged 52 from a small, unspecified town in Slovakia, who has been hospitalized at the infectology clinic of the University Hospital in Bratislava. No recent travel history abroad, but his son – who does not show any symptoms of the virus – has been to Venice, Italy [source] [source]
- 59 new cases in Belgium: total more than doubled since yesterday [source]
- Total number of COVID-19 cases worldwide tops 100,000
- 1,234 new cases and 16 new deaths in Iran [source]
- 28 new cases in Malaysia [source]
- 1 new case and 3 new recoveries in Taiwan [source]
- 5 new cases in Estonia [source]
- 42 new cases in Sweden. Total now tops 100 [source]
- 2 new cases in Indonesia [source]
- 1st case in Cameroon: a 58 years old French man who entered the country from France on Feb. 24 [source]
- 1st case in Serbia: a 43-year-old man who traveled to Budapest [source] [source]
- 1st case in Vatican City [source]
- 1 new case in India: a person who has travelled to Thailand and Malaysia [source]
- 1 new case in Pakistan [source]
- 3 new cases in Finland [source]
- 56 new cases in Japan
- 309 new cases and 1 death in South Korea [source] [source]
- 2 new cases in Norway (Bærum, Viken County). Total now tops 100 [source]
- 2 new cases in the Philippines: a 48-year-old male Filipino with travel history to Japan and a 62-year-old male Filipino with no overseas travel history [source]
- 17 new cases in Canada, including: [source]
1 in Ontario: a person who traveled to Las Vegas for an international conference [source]
8 in British Columbia: 1 has no travel history, 2 had recently returned from Iran, 4 are linked to a previously confirmed case, 1 is connected to University Canada West where a presumptive case is being investigated [source]
1 in Alberta: a woman in her 50s from the Calgary area who had been on board of the Grand Princess cruise ship, which is currently quarantined off the coast of California awaiting tests for all passengers and crew [source]- 1st case in Bhutan: a 76-year old American tourist who arrived in Bhutan on March 2 via India. [source]
- 143 new cases (126 in Hubei), 30 new deaths (29 in Hubei) and 1,681 new discharges occurred in China on March 5, as reported by the National Health Commission (NHC) of China. [source]
Here’s what should have happened.
We should have started with aggressive testing of all returning from China. Followed by testing in China towns around the US. Cities with large Asian populations. Cities with direct air links to China. Cities with lots of Chinese tourists. Then expanded those to South Korea, Italy and Iran. When positives showed up testing of family, contacts etc. Testing of anyone symptomatic in surrounding areas.
Testing of a number of asymptomatic people in areas with a known outbreaks. Finally random surveillance testing in other areas.
Last I saw we have tested under 2000 people total in the US. It’s been a complete shambles. And I’m afraid there is going to be hell to pay for this screw up.
I don’t disagree, but the question for me remains: what test? I have read references to a “swab test” which I presume is collecting mucus or saliva from the nose or mouth. Presumably those swabs are sent somewhere for microscopic analysis by someone to detect the presence — in the sample — of the specific virus. I don’t know what the testing/results time cycle for that is and what people are supposed to do while awaiting results. I also don’t know the level of false negatives.
On the average in the US there are 16% more people infected each day.
In Houston the VA hospital will start screening people who enter. Staff who are not veterans who fail screening will be turned away and told to seek care and advice about being quarantined. Veterans are sent to the ED if they fail screening. There are now 8 cases in the Houston area, mostly travel related. One is a staff member of Rice University. They are in the process of tracking down all this person’s contacts and have sterilized the building where he or she works.
Your strategy is pretty much what this CEO did successfully in Germany that I wrote about yesterday from yesterday’s WSJ, “The Company That Fought the Coronavirus and Won“:
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Obviously there have to be accurate tests to make this strategy work.
And strong executive leadership of a defined population unit–an island like Nantucket, a town, or company.
I don’t understand why the CEO has the test we need and we don’t. It’s not like we are in Day 47 of this epidemic or something. Oh, wait . . . we are!
It is obvious the “test kits” are a Dem excuse to attack Trump on social media. I am not arguing their usefulness to doctors, but the reality they can’t stop the spread of a virus. Otherwise, flu would be contained since we test sick people in flu season. You would have to test 330,000,000 citizens plus immigrants weekly, symptomatic or not, to get the big picture. The screen shots I posted show the high volume of air and shipping traffic. The last two show just two cruise ship ports, on one day, each ship can carry 1800 to 5000 passengers plus crew. On Sunday, the scene will be repeated with a different batch of ships. Italy doesn’t have as many confirmed cases as there are passengers on the Allure of the Seas (and sister ships of that class). If people come in with sore throat and cough, the medical treatment will be the same unless it progresses into respiratory difficulty as the flu does. Tell all sick to stay home. Chasing down all who were in contact is time consuming. If they were infected, they probably have infected others who they can’t identify anyway. I expect this to spread just like the flu, some to die while most will recover, just like the flu, and labs will eventually figure out a vaccine to lesson the impact. Dems will try to unfairly tarnish Trump while still fighting for open borders. Florida Dems will attack Matt Gaetz over masks while not wanting to close off ports, overseas travel, and amusement parks there for fear their economy will suffer. Hysteria will run its course and summer will be normal.
A couple of comments: (1) The CEO did a great (and commendable) job of containing one specific outbreak within a clearly defined population, and (2) people, including his employees, may get sick anyway from the propagation of the virus in Germany through other vectors over which the CEO has no control.
And regarding testing: I have been trying to understand what “testing” means in the various reports and accounts. The current gold standard test (CDC 2019-Novel Coronavirus (2019-nCoV) Real Time RT-PCR Diagnostic Panel) is described at https://www.fda.gov/media/134922/download.
“PCR” stands for “Polymerase chain reaction (PCR) is a method widely used in molecular biology to rapidly make millions to billions of copies of a specific DNA sample allowing scientists to take a very small sample of DNA and amplify it to a large enough amount to study in detail.”
I encourage you to skim through the link. This ain’t no “pee on the stick” pregnancy test. Here are some quotes from the link:
Just so, @eherring. Job #1 is to protect the health care system while dealing with the most acute cases. We have to expect some economic difficulties, but we must not make it worse through panic. Our free market system is better positioned than most to handle the shock although we have to work to get back some domestic capabilities that we off-shored. Government will hopefully not be stampeded into making things worse. (Compare Coolidge vs. Hoover-Roosevelt responses to economic shock.)
Keep Calm and Carry On.
I love this part under limitations: “This test cannot rule out diseases caused by other bacterial or viral pathogens.”
Okay. So there is presently no definitive test for hospitals to work with.
I remember when my kids were tested for strep throat. There were instant A tests that could be done in the doctor’s office and three-day B tests that went off to a lab. If the A test came back positive, the doctor put the kids on antibiotics and told them to stay home. Strep would have infected entire schools without those tests to identify the kids who had it and keep them home from school. Similarly, we have to have reliable metrics to combat the new infection.
So I will add “accurate tests” to my prayer lists for “treatments” and ” vaccines.” :-)
I also think we need new antibiotics. I’m betting that some of the deaths we are seeing are the result of treatable secondary infections. I understand the C-diff risks, so I understand why the doctors are hesitant to do this on a massive scale–not to mention the fact that our antibiotics come from China mostly. Using the antibiotics we now have would lead to the evolution of superbugs, use up whatever supplies we may still have on hand, and we would be simply exchanging one set of problems for another. But we need an aggressive antibiotic development program.
A friend of my husband used to work for Merck. He traveled all over the world. He told us one night that his job when he wasn’t working in his sales function was to scoop up soil samples everywhere in the world he went to give them to the antibiotic development department. :-) He said antibiotics occur naturally in the environment. We just have to find them.
I’d be curious to know what exactly these testing kits are and why they’ve been such a problem to implement and get out there. I work with plenty of virologists, and they all seem to be of the opinion that making a test for at least Corona Viruses in general (if not COVI-19 specifically) shouldn’t be that big an issue. IF the test is some sort of PCR reaction (and it sounds like it is) all you really need is a good set of primers. You don’t even have to make them just release the sequence and have hospitals order the primers from various private companies that supply them to labs. There are off the shelf kits that will extract DNA from samples, and once you have that there are literally hundreds of different PCR kits out there off the shelf that will work with any set of primers.
My gut tells me the CDC was over thinking this whole thing from a technical perspective, probably because this is how Government does its thing in general.
So most of the testing is to get nasal mucus like a flu swab or sputum, and it’s a PCR test for viral RNA.
Of course they would help. You have 2 ways to stop an epidemic. A vaccine , or social distancing, quarantine and contact tracing. It’s worked well in those countries that used it aggressively, particularly Singapore and it’s helped in South Korea to slow the growth. And slowing the growth is key if you want to keep the medical system from being overwhelmed.
We don’t do that for the flu because we know it’s not worth the effort. Very few people need to be hospitalized for the flu, and less then 0.1% of people die from the flu every year. Cost > Benefit.
OK. This got my attention. I was in Vegas last year for March Madness. It was packed with lots of people from all over (most folks were wearing a school shirt)–crowded around tables and TVs for a 3 hour game all shouting and high fiving. Many people just circulating and waiting in line for restaurants and buffets and shows. It seems like a place tailor made to share and widely distribute a contagion.
The source said nothing of the conference.
CDC just advised everyone over 60 to stay at home as much as possible.
EDIT: This is not exactly correct. CDC issued guidance on Thursday suggesting older adults in communities where an outbreak is occurring should stay at home as much as possible. Shame on me for relying on CNN summary! Of course, most metro areas at this point have an outbreak. Just had our first community case in Phoenix yesterday.
And I think it is important to also emphasize a point Dr Fauci made in the press conference with Vice President Pence: a lot of older people have “underlying health issues”, but not all health issues represent a risk for COVID-19. For example, controlled hypertension does not make you more at risk with COVID-19, while COPD would. The focus is on lung, heart and kidney disease, not arthritis or cataracts.
What the CDC is suggesting is very reasonable advice. I like it. :-)
The specific language on the CDC website refers to “Older adults and people who have severe chronic medical conditions”.
I watched a little bit of the Trump press conference from CDC on Friday. Lots of questions about testing. One guy said the first test was developed rapidly after sequencing. Probably as fast as WHO or Europe countries. The problem was getting samples shipped to CDC. So they sent the test kits to regional labs, but regional labs were not getting good results. They figured out it was too unreliable to test for 3 criteria and switch to 2 criteria, which the regional labs had better quality. Makes sense to me. It feels like the media are expecting the government to detect all and prevent all infections, which is probably good for ratings and a handy stick for Trump bashing. The real goal and it will be a challenge, is to use social distancing to keep the number of infected people from overwhelming the healthcare system in any city.
I think the problem was the CDC stepped in and took complete control, and stopped any universities or health departments from developing their own tests. They then in classic Big Government fashion proceeded to bungle and fail spectacularly. One article I read yesterday stated a reason for the failure of the CDC test was they trie to construct a “cadillac” test that also tested for MERS and SARS as well the current virus. It was too complex and proved unreliable. In the meantime we lost at least a month of testing. To put that in perspective Italy, 14 days ago had 20 cases. Look where they are today.
I think the President could set an example here by cancelling his rallies for the next two months and urging other politicians to do the same. This would trigger additional actions by others to cancel large meetings and events. Covid is going to spread but the degree and speed with which it does is important in its ultimate impact. We now have enough examples to show that measures taken early on can be effective but if you wait too long much less so.
He should stay at home, make YouTube videos., and wait for them to be shadowbanned.
Hm… well that makes sense it seems to me though that trying to centralize the process didn’t really work for them, and in a way there was no need to centralize it at first. This is a project for which crowd sourcing is an ideal solution. Labs in the US, Europe, and Asia could each have come up with different tests. The CDC serving as an information and resource sharing hub would have been more useful. Once you have a few working tests they can serve to disseminate the information. Like I said nothing about these tests is anything that can’t be bought off the shelf by individual hospitals/labs. If they had issue getting positive sample from China or Korea to use as positive controls that would certainly slow things down, and that is where good international organizations (again acting as clearing houses for such resources) would come into play.
I think if they have a working set of primers now, just release the sequences so that any lab can do the test, just to get capacity up. It is literally a process that costs a few dollars per reaction, where everything can be bought off the shelf.
I think it would definitely be prudent to encourage at least all old people (60+) to avoid unnecessary public gatherings for now. They are the most at risk group and so should take extra precautions.
https://www.japantimes.co.jp/news/2020/03/08/national/7-eleven-yamanashi-coronavirus/#.XmWNBdApB-F
A young 20-something in Japan, has now contracted SARS-2-CoV and also meningitis.
In UK, they are talking about rationing care.
Don’t mess around. It’s not the flu.
” I think the problem was the CDC stepped in and took complete control, and stopped any universities or health departments from developing their own tests. They then in classic Big Government fashion proceeded to bungle and fail spectacularly. One article I read yesterday stated a reason for the failure of the CDC test was they trie to construct a “cadillac” test that also tested for MERS and SARS as well the current virus.”
The simple fact is that the CDC and FDA have way too much authority. Multiple approaches was always the way to go, and to stop Universities and Laboratories from developing their own tests makes absolutely no sense, and is perhaps a violation of their rights.
I am an architect. If I design a building and a person gets hurt or dies due to some negligent part of my design, I may be criminally liable and could potentially be sent away for manslaughter. In my work I have to check out every potential flaw, whether or not some less than official authority says it’s okay. or not. That is why I am so appalled at all these commenters who are so afraid of talking about various pieces of information that do not come what they think are official “authorized :sources, if there is even such a thing anymore. In my job, I have to check it all out and deal with the worst case scenario. Always.
But that is not what the CDC and FDA have done. They have been grossly negligent in their approach and have not considered from my point of view, the worst case scenarios that could happen with this pandemic.
Similarly, the CDC and FDA have taken a “by the book” slow as molasses approach to this pandemic, which has a great potential of causing a great many to die. In my book, if people start to die in droves then the upper management of the CDC and FDA should be held criminally responsible for their deaths for their response has been worse than GAWDAWFUL.
Coming soon: a home test kit for 2019-NCoV
Aaaand then there are the idiots who should be locked up. Except somebody would have to look after them.
There was a confirmed COVID-19 case in St. Louis, a 20 year old woman who was studying in Italy. She was sent home from the hospital. She and her parents were told to “self-quarantine” at home.
But they went to a preparty and then the school father-daughter dance.
The whole school is now closed.
The St. Louis Post-Dispatch reported:
Ya think?