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COVID-19 policymaking has been at the center of attention in the United States since early 2020. Over the past two years, the cases, hospitalizations, injuries, and deaths have had multiple cycles with no clear end in sight. By the end of 2020, a number of different vaccines had become available to prevent the disease. Two of these, the Pfizer and Moderna vaccines, rely on a new mRNA technology. With great expectations, both of these were approved by the Food and Drug Administration last summer, a step taken only when the FDA determines that vaccines (or other drugs or medical devices) “meet the FDA’s rigorous scientific standards.” The FDA also continuously updates its recommendations for approved booster shots for COVID. The work of the FDA has been complemented by that of the Centers for Disease Control and Prevention (CDC), which as of December 29 had adopted a categorical position of recommending that all individuals get their initial or booster shots of the vaccines as soon as possible.