Practicing pharmacy over the years you start to get a feel for what works and what does not.  Feedback is constant both welcome and otherwise.  Some drugs just seem to work for a wide range of people. Amoxicillin, cefdinir, and azithromycin are just a few of our greatest hits from behind the counter.  On the opposite side, we have drugs that despite approval and mass marketing never really seemed to take off.  Tamiflu is a great example.

It was hailed and marketed as a cure for the flu and there was a point due to demand, I would spend an inordinate amount of time opening capsules to compound it into a suspension for younger patients when the commercial product would go on backorder.  Despite dispensing a lot of it, the rave reviews never seemed to follow and it would be prescribed less and less.  The most loaded question in healthcare is how was your day and I recall once quipping to another pharmacist “just another day padding Roche’s bottom line, how about you?”