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Flowers for Algernon is a short story, further developed into a novel, that tackles the themes of isolation that high IQ people face. Charlie is on the lower side of the IQ distribution. After a lab mouse, Algernon, is successfully treated with an intelligence-increasing procedure, Charlie subjects himself to the same and his IQ triples. He finds that he can no longer relate to most people and falls into depression. His IQ then regresses as a result of a flaw that he discovers in the experiment. There’s a lot more to it, but that’s the gist. Ever see “The Simpsons” episode HOMR? Where Homer discovers that he’s an idiot because he has a crayon stuck in his brain? And removing it makes him extremely smart, only to discover that happiness doesn’t come with intelligence? Same general idea.