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I would start by taking the various department heads in a room to get my point across: Professionalism and competence earn respect. At the beginning of the Wuhan Coronavirus pandemic, 80% of people in the US trusted the CDC for information on the pandemic. It is now near 50% and falling. If the CDC is not trusted by the American people to provide advice on a pandemic, what is its purpose? (Aside from paying bureaucrats.)
The CDC must be a conservative organization. One of Conquest’s laws of politics is that any organization that is not explicitly conservative will become liberal over time, so the CDC must be conservative. What this means in practice is a presumption against restricting people’s freedom. People need to take risks and determine what is safe. We give them information so that they can make an informed decision. When we practice quarantine and lockdown measures, it should be treated like going to war or invoking martial law – never done lightly.