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I am making this post without having an answer to offer. But I am hoping that it will stimulate some discussion that will aid all of us in some upcoming important personal decisions — if we get to make them.
Tom Renz, an attorney and not a scientist, has a Substack post in which he tries to articulate that the Covid vaccine (and others?) are not using “messenger” RNA (mRNA) but “modified” RNA (modRNA). This difference seems to be at the heart of the “gene modification” debate.
Because mRNA is a weak particle and breaks down easily with a relatively lower risk of messing with your genetics than other gene therapy products (like modRNA) that is what is always talked about in the jabs. The problem is that it is a lie.
(From the Pfizer label)
Notwithstanding the age limitations for use of the different formulations and presentations described above, individuals who will turn from 11 years to 12 years of age between doses in the primary regimen may receive, for any dose in the primary regimen, either: (1) the Pfizer-BioNTech COVID-19 Vaccine authorized for use in individuals 5 through 11 years of age (each 0.2 mL dose containing 10 mcg modRNA, supplied in multiple dose vials with orange caps); or (2) COMIRNATY (COVID-19 Vaccine, mRNA) or the Pfizer-BioNTech COVID-19 Vaccine authorized for use in individuals 12 years of age and older (each 0.3 mL dose containing 30 mcg modRNA, supplied in multiple dose vials with gray caps and multiple dose vials with purple caps).
I recall that early in the vaccine rollout there were claims and denials that the vaccine would modify your DNA. If Renz is correct, the denials would be marginally true for mRNA, but not at all for modRNA. Renz links to a current Q&A from Pfizer:
What formats of mRNA does Pfizer use?
Nucleoside-modified messenger RNA (modRNA): Our first approved mRNA vaccine, the Pfizer-BioNTech COVID-19 vaccine, utilizes modRNA. modRNA stands for nucleoside-modified messenger RNA and in the synthesis of the RNA used in this vaccine platform, some nucleosides, which are important biological molecules that constitute DNA and RNA, are replaced by modified nucleosides to help enhance immune evasion and protein production. modRNA instructs our cells to produce desired proteins. We are also leveraging modRNA in our investigational flu and shingles vaccines.
Self-amplifying mRNA (saRNA): saRNA is a platform that uses a much larger molecule because not only does it encode the antigen of interest, but four additional proteins. These extra proteins allow the cell to make more copies of the mRNA, resulting in more protein being expressed from a smaller dose. Pfizer is exploring, testing, and refining multiple constructs in order to advance saRNA technology, currently for its flu program.
According to Renz:
The biochemical modifications that have been done to RNA have altered it substantially. These alterations were done for the purpose of allowing the use of these various RNA technologies to modify the human genome. In light of the complexity of the human genome we not only have no idea of the consequences I do not believe we can truly state what changes will ultimately be permanent and which will be temporary.
So I invite commentary. There are stories out there that some variant or other of Covid is making a comeback and that government might try to reimpose behavioral controls. There are reasons not to comply regardless of any dangers associated with the vaccine. And the stories about “shedding” by vaccinated persons might make it moot, if true (passive “vaccination”).
But what is true? And is this technology a feature of all Covid-19 vaccines, some vaccines and not others, just Pfizer?Published in