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Vaccine? No, Not Really.
The jab is a vaccine, or at least that’s what it’s called, but it really isn’t. It is not a vaccine as vaccines were once understood. It is an invasive genetic delivery therapy and consists of an injected mixture containing nanocarbon fibers, lipids, and strands of mRNA designed specifically to reprogram a cell’s DNA, its genes, and its purpose. Instead of say, assembling within a scaffold of proteins designed to contract on command (example: muscle cell), the former muscle cell is reprogrammed by the mRNA to give up its duties and madly make COVID spike proteins until it burns out.
mRNA must work quickly or it breaks down. It cannot enter a cell on its own. Enter dense lipids, to protect the mRNA, and carbon nanoparticles to penetrate cell walls and allow the mRNA to enter a cell. The manufactured spike proteins leak out of the now compromised cell and drift though the circulatory and lymphatic systems, until they locate an ACE2 receptor on the surface of cell and bind with it. In theory, this would close a pathway for a potential COVID cell infection. In addition, these circulating spike proteins will eventually be recognized by your immune system as invasive and will prompt an antibody response to neutralize them. These same antibodies would respond to actual proteins on a COVID spike, effectively neutralizing any COVID viruses post-exposure.
Historically, vaccines for viral infections have been incredibly effective. Small pox? Eradicated. Polio? Virtually eliminated. Chickenpox, the mumps, the measles, rubella, whooping cough? Gone. In the public mind, viral vaccinations are miraculous. So, when this new mRNA technology was elevated to “vaccine” status, the CDC and NIH effectively tapped into the public’s vaccine goodwill. But this new “vaccine” wasn’t a vaccine at all. It was gene therapy, both unproven and unapproved. The definition change is an old-fashioned bait and switch.
Redefining vaccines to include invasive mRNA genetic therapy also served another, more nefarious purpose. It allowed the manufacturers to hide behind the legal liability shield provided generally to producers of vaccines. Had the therapy been relegated to therapeutic status, producers would have to defend themselves against civil claims for possible harmful, even fatal, side effects. And they might lose.
I submit, dear readers, that had the public known these things, many more folks would have been reluctant to participate in mass injection. Further, if they knew that cell lines harvested from aborted fetuses were needed to develop the tests for the efficacy and safety of this therapy, even more people would have balked.
Further, the NIH, CDC, and vaccine manufacturers obviously did not know whether these new “vaccines” would be effective. Authorizations were “emergency”. They hoped they would be effective and if wishing were real, they all would have been, but wishing is never a good reason to place a bet. These new vaccines have now proven to be largely ineffective. They are not lasting, hence require constant boosters. They do not prevent infection, hence breakthrough cases are now the norm. They do not staunch infectiousness as those who get COVID, even if vaxed, boosted and asymptomatic, still shed virus and infect others. They are not durable as new strains of the virus, like Omicron, are not deterred by the vaccines. The only thing we know for certain: breakthrough cases are less mortal than infections in the unvaxed. However, as with all respiratory viruses, evolved variants are also proving to be less harmful and more virulent than their predecessors
It is clear now that mRNA so-called vaccines seem to do only one thing; they reduce the severity of a COVID 19 infection. There is a medical term for a treatment that reduces the severity of a viral infection: a therapeutic. Government agencies have oversold this mRNA technology at every turn, even elevating it to “vaccine” status. This was an abuse of language for political ends, largely benefitting the virus purveyors and their investors. It’s time this mRNA therapy is purged from the definition of what constitutes a vaccine. It is an invasive gene therapy. At best, mRNA therapy has proven to be only therapeutic, a treatment whose benefits are limited and may not outweigh the risks for many easily discernable segments of the population. The vaccine liability shield should not apply to these therapies. Perhaps it is time to alert the trial lawyers. The immense gains accumulated by the hucksters pushing this stuff have proven illegitimate. And the therapy itself may well prove harmful to many while those harmed have had no good recourse.
Published in General
Yes, numerous writers here and in other pro-covid articles, have said that the mRNA is destroyed after making a single spike protein.
I doubt it. I never heard such a claim here or anywhere else. I suspect you’re getting confused with the fact that the mRNA is not capable of reproducing itself.
Funny. I’m pretty well read and never heard that one. I read this over a year ago:
https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/
Pretty clear description of how the mRNA vaccines work. Particularly how each strand can make many spike proteins before it wears out.
Are you sure you aren’t misremembering?
Maybe it was my mistake. Since I’ve never read anywhere on Ricochet about self-replicating mRNA, perhaps I just assumed no one was talking about them.
mRNA vaccine constructs. Constructs are classified as either nonreplicating (a) or self-replicating (b) and composed of a 5′ m7G cap, 5′ and 3′ untranslated regions (UTR) which flank the nucleotide sequence that encodes the immunogen of interest, and a 3′-poly(A) tail. Additionally, self-replicating mRNA constructs encode an RNA-dependent RNA polymerase (RDRP) complex that transcribes and amplifies the message.
Self-replicating mRNA constructs (replicons) encode an RNA-dependent RNA polymerase (RDRP) complex required for self-amplification as well as the components found in nonreplicating constructs (Figure 1B) [19,20]. The RDRP complex is often derived from alphaviruses, e.g., Sindbis virus [19,20]. Self-replication increases the magnitude and duration of construct expression and, consequently, production of the encoded immunogen. In non-human primates (NHP), low doses of self-replicating mRNA vaccine induced enhanced immunogen production for an extended duration, where production peaked on day 3 and remained detectable for more than 14 days following immunization [20]. Similarly, immunization with a self-replicating mRNA construct induced more protein synthesis for a longer period of time and a greater immune response in mice, compared with a nonreplicating mRNA vaccine [21]. An additional advantage of self-replicating mRNA constructs is the ability to incorporate multiple gene sequences into the same replicon, allowing the expression of both the target immunogen and immunomodulatory molecules such as CD40L, CD70, OX40L, and GM-CSF to enhance potency [22,23].
Cellular uptake and expression of vehicle encapsulated mRNA vaccine constructs. Nonreplicating and self-replicating vaccine constructs (NRC and SRC, respectively) are encapsulated in LNP to prevent degradation and to promote cellular uptake (a). Uptake of the mRNA–LNP complex is mediated by endocytosis (b). mRNA vaccine constructs are released from the endosome into the cytosol where NRC are translated by ribosomes (c) and the immunogen produced (d). SRC are translated, producing the RNA-dependent RNA polymerase (RDRP) necessary for self-amplification and production of the immunogen (e). Immunogens (sequestered intracellularly, incorporated into cell membranes or secreted) induce humoral and cell-mediated immune responses.
The vaccines are not a self-replicating mRNA. They do occupy a spot in the cellular protein fabrication machinery for an extended length of time. It is a deep dive, but I do highly recommend that linked article in #93.
I scanned through the article (and saved it for later, thanks) and didn’t see any explicit number of spikes per mRNA molecule, but that doesn’t mean it’s not there, and doesn’t mean it’s not implied by the process it describes.
It does that the Pfizer vaccine contains thirty micrograms of mRNA, and that’s an awful lot of single molecules I would think. Nonetheless, what I did see was this which could be interpreted very widely either way:
* This doesn’t imply multiple spikes per mRNA protein; it may very easily only mean many, many mRNA.
The diagrams in my earlier comment refer to non-replicating and self-replicating mRNA, and so far as my cursory scan goes, this article doesn’t address this.
I would be very surprised if someone could specify a specific number. The number of spikes produced depends in part on the raw materials available in a cell, which I presume varies from cell to cell and possibly from one day to another, depending on the person’s chemical state. And on the availability of ATP to provide energy for the process. It would also depend on the state of the body’s machinery that goes around and degrades any mRNA that doesn’t belong there. And probably on many other factors, as well.
Until you posted this, I didn’t know there was such a thing as self-replicating mRNA. Usually RNA has to get transcribed to DNA before more RNA can be produced from it. But self-replicating mRNA has apparently been used in vaccines to get it to produce more antigens over a longer period of time in order to provoke a better immune response.
Here is the full article from which you got your figures: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103517/
I’ll be more careful in the future not to say categorically that mRNA cannot self-replicate. Thanks.
I read the first half or so and skimmed the rest of it. But I saved it. :)
1 spike is a knowable number.
This is new to me. I’ve always been under the impression that RNA is transcribed from DNA, and acts within the cell independently of DNA. The science seems to be turned on its head.
Reverse transcriptase, which is what makes this rna to dna transcription possible, was a big deal when it was discovered around 1970. (I thought it was several years later than that, but wikipedia says 1970.) One of the discoverers was David Baltimore, who was the mentor of the Vincent Racaniello who runs the This Week in Virology channel that I refer to a lot in these discussions. Some viruses depend on the RNA to DNA transcription for reproduction. Coronaviruses do not. (I had to look it with the help of a chart that I’m supposed to have memorized for Racaniello’s online course.)
Maybe if I had kept up with his course I would have known about self-replicating mRNAs.
100 is a number better able to elicit an immune response from your body. The human body contains dozens of trillions of cells, so one mRNA molecule producing one spike is not going to be very helpful in all that immensity.
So then are you agreeing with me that the viral RNA molecules do not practically transcribe themselves into human DNA?
Well then, a hundred is far less than the number of single mRNA molecules in the 30 mcg of mRNA found in the (weak) Pfizer vaccine. So they don’t have to replicate themselves at all. Which means, one mRNA molecule per spike that is produced. But this is all just speculation, as far as I can see.
Thanks for that. When you learn, I learn.
No, that is how we got some of the DNA that we have — through pieces of virus that got inserted in reproductive cells and then passed on to us. This article says that eight percent of human DNA was originally viral DNA, and then goes on to mumble about another 40 percent. How much of it is thought to actually do anything other than come along for the ride and get copied when cells reproduce, I don’t know: https://www.cshl.edu/the-non-human-living-inside-of-you/
It’s probably just a superstitious fear on my part, but that’s why I prefer the mRNA vaccines over the Johnson & Johnson one, which does some of its work in the cell nucleus. I’d just as soon keep some distance between my genome and the vaccine RNA. If I understood in more detail, I’d probably get over it.
I was referring to each mRNA molelcule producing a hundred spikes. I don’t know what the actual range of numbers is.
I don’t think I understand what you’re getting at. But no, the mRNA molecules don’t need to replicate themselves, and I don’t think they do in the case of these vaccines. They just need to produce enough spikes for your body to view them as a threat and develop an immune response to them.
I had Chauvinist the Elder (who studied vaccinology at Hillsdale in her microbiology class just as COVID was getting going and is majoring in microbiology) read through this and she’s pretty sure the mRNA vaccines are Figure (a), which is also what appears in Phil’s link as the decoded mRNA vaccine. She explained the article sounds speculative about the possibility of using the polymerase to extend the efficacy of the vaccines, but all the polymerase does is replicate the (nonreplicating) mRNA sequence that follows it. She thinks it would be something requiring extensive laboratory testing, though, as the risk of the polymerase getting loose in the cytoplasm and replicating other mRNA strands present there might be significant. However, in any case, the nucleus (DNA) is never under threat from mRNA. It’s just not allowed into the nucleus.
Also, every virus and every (dead or attenuated virus) vaccine injects “foreign genetic material” into your body (that’s what viruses and related vaccines are). But, it sure sounds scary when you put it that way. The spike proteins formed in response to the mRNA vaccine are assembled from the building blocks already present in the cytoplasm of the affected cells. The nonreplicating mRNA strands of the vaccine act like the conveyor belt on which the (multiple) spike proteins are assembled. But, the building blocks are already part of you.
It’s fascinating stuff.
And, all the proteins in your body eventually breakdown, which suggests the “loose” vaccine spike proteins do too. Unlike the COVID virus which can be replicating like mad until either your body’s immune system overcomes it, or doesn’t.
And still the number 1 is knowable. Who really knows what average number of spikes (if any number greater than 1) an mRNA code makes.
Definitely more than one. It would be incredibly inefficient for it to be one for one. The mRNA strand is the assembly belt. Multiple spikes are being produced and delivered off the line. How many multiples, I don’t have a clue, but definitely more than one.
Why does it matter if the number is knowable? As to who, I presume the vaccine researchers and pharmas find it interesting enough to come up with some estimates. I’ve never cared enough to try to find out.
This makes sense. I say things that make sense all the time that are just educated conjecture. But among those who actually know, what do they say? I mean theory doesn’t prove anything. But experimentation does. And the interpretation of retrospective studies is really just conjecture. Does anyone actually know on average how many spikes a given human cell actually makes before it explodes or is otherwise shut down? I’m just curious as to what really is.
Well, it’s part of understanding what’s going on with the vaccines and the human cells they infect. For most of the past year, for example, all the information that I’d seen stated that the spike proteins that the human cells produce join and become part of the human cell membrane. But lately I’ve read that they are all or in part free-floating spikes. This makes their migration through the body via lymphatic fluid and blood much easier.
People are speculating (which in itself is fine) based on very incomplete information.
I’m summarizing Elder’s explanation for how mRNA works. It provides the instructions for how to assemble parts (amino acids? I forget what she said.) already present in the cytoplasm, and the attachment points for that to happen — the assembly line. I suppose someone could figure out how many by studying the decoded mRNA vaccine strand in Phil’s link, but that wouldn’t be me. My answer would be, “enough to provide limited and, now we know, transient immunity.” I was hoping to get more that 6 months out of Pfizer, but such is life.
And, just giving my perspective, but when you use words like “explodes,” it seems you’re going for dramatic effect, but I don’t think loaded language is helpful to understanding. I suspect the cell rather decomposes into spikes and other of its remaining component parts. Cells break down all the time; these cells do it in a way to promote an immune response after having been affected by the vaccine.
Elder said I probably misstated the timeframe for breakdown of the spikes. I said “in a matter of days,” but it could be longer than that. They do breakdown though, like other proteins in the body.
Don’t know, but the machinery in the cell that is “hijacked” normally makes many protein molecules from other mRNA strands amidst the injected ones. The idea that the mRNA kills the cell or breaks it somehow is somebody’s assumption. Please back that assumption up. Note, real virii do damage host cells, because they include self-replication. These vaccines don’t–they just deliver the mRNA.
Did you mean “affect?” Because an infection implies replication. Like the COVID virus.
This is what bugs me about conversations with vaccine skeptics. I never hear their concerns about how the Chinese communist manufactured virus affects the body in the short or long term. It’s always about the American made vaccines and the spikes they produce.
I sincerely believe anything the mRNA vaccines might do to you, the virus might do 100x worse — with the possible exception of vaccines which are inadvertently injected directly into the bloodstream. It seems when that happens, the brain and heart (which do not regenerate new cells like the rest of the body) can suffer serious damage. Which is why we should all insist that any mRNA vaccination is preceded by aspiration to ensure the needle is in muscle tissue and not a vein.
Okay, it literally ruptures and the contents spew outward. Explodes is what it is. There’s nothing to read into it. :)
The mRNA destroys the cell. No cell survives mRNA capture.
Added: and from I had formerly read, the spikes become part of the human cells’ outer membrane, which is then physiologically compromised and also now the subject of immune attack.